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KMID : 0378019620050090107
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New Medical Journal
1962 Volume.5 No. 9 p.107 ~ p.110
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Urine-PASTests in Pulmonary Tuberculosis Patients Treated at The 18th Army Hospital
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Abstract
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Para-aminosalicylic acid (PAS) is frequently used in conjunction with other antituberculous agents in the combined therapy of tuberculosis.
Many patients do not tolerate PAS in adequate doses because of side effects of the inconvenience of ingesting many tablets of relatively large size throughout the day. Furthermore, it is the general experience among physicians working with tuberculosis patients that many who do not take the PAS do not inform their physicians of this fact.
Three hundred and seventy-nine hospitalized pulmonary tuberculosis patients prescribed PAS as one of their antimicrobial drugs were subjected to an urine-PAS tests at first. The tests were done secondly on 390 patients after a strong persuation and adequate explanation of the necessity of regular chemotherapy.
The percentage of negative urine-PAS test before persuation was 10.8 per cent while that of after persuation was 5.8 per cent. The percentage of negative tests were higher in patients with less extensive disease and with negative bacteriologic findings. Negative rates were higher in patients with higher military ranks. Nagative rates increased also with the length of time that PAS was prescribed.
Persuation and adequate explanation of the necessity of regular chemotherapy reduced the incidence of negative tests for urine-PAS
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